The review summarizes results of clinical studies investigating the influence of a combination of plant extracts with aminoacids, functioning as NO-donors.

Prelox®, a combination of French maritime pine bark extract with L-arginine aspartate, enhanced activity of endothelial nitric oxide synthase (e-NOS) and reduced plasma concentrations of the e-NOS inhibitor ADMA (asymmetric dimethylarginine), thus enhancing bioavailability of nitric oxide.

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